Innovative non-animal testing methods showcased by experts, despite U.S. federal agency absence
We explored the latest progress in animal-free science at one of the largest scientific gatherings in the U.S., last week.
Experts from across the toxicology field highlighted the latest research and testing methods shaping the future of the industry, at the Society of Toxicology (SOT) 2025 annual meeting, in Orlando, Florida.
While animal-based testing methods still dominated much of the conference, there was a clear shift toward non-animal alternatives, reflecting a growing commitment to more humane, innovative and scientifically advanced approaches.
Our Deputy Director of Science & Regulatory Affairs, Laura Alvarez, engaged with industry leaders and researchers, discovering firsthand how non-animal testing methods – like organ-on-chip models, computational toxicology, and advanced in vitro systems – are paving the way for more efficient, cost-effective and reliable results. These innovations were on full display at the Tox Expo, an area of the meeting where companies showcased their groundbreaking, non-animal technologies to build new relationships and attract customers who are exploring alternatives to animal-based testing.
In addition to the Tox Expo, key presentations and workshops illustrated how modern technologies, including artificial intelligence, are transforming toxicology research. These methods are not only providing more reliable data but are also aligned with the global movement to reduce animal use in scientific testing.
However, a notable absence was deeply felt at the meeting: key U.S. federal agencies – such as the Environmental Protection Agency, Food and Drug Administration, and National Institutes of Health – were unable to attend due to travel restrictions on federal employees and employment changes implemented by the government. This was particularly disappointing, as these agencies have been at the forefront of advancing non-animal testing methods in recent years. Their absence left a gap in the discussions, preventing attendees from engaging with their recent work and missing the opportunity to hear the U.S. perspective in global conversations on non-animal methods.
Despite this setback, the SOT 2025 meeting emphasized the critical need for continued investment in non-animal research. It was a powerful reminder of the scientific community’s dedication to advancing humane testing methods that go beyond outdated, unethical tests on animals. However, progress is still slower than we would like, and more collaboration, funding, and regulatory clarity on the use and acceptance of non-animal methods are crucial for driving global harmonization and accelerating meaningful change.
Laura said, "The SOT 2025 meeting highlighted the tremendous progress being made in non-animal testing. While animal-based methods still dominate, it’s clear that the future of toxicology is moving toward more ethical, innovative solutions. It’s unfortunate that the U.S. federal agencies couldn’t be there to discuss their recent advancements in non-animal approaches, as their leadership in this area has been invaluable. We hope they will continue their important work in advancing non-animal methods and look forward to the opportunity to engage with them at future meetings to discuss these vital contributions."
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